ABSTRACT
Introduction: Tumors like Odontogenic Keratocyst (OKC), Dentigerous Cyst (DC)and Pyogenic Granuloma are frequently oc- curring in the oral cavity with each of them having relation to angiogenesis. Higher angiogenesis may be associated with increased tissue metabolism, more aggressive biologic behaviour, and increased recurrence and growth rate. Tumor growth is dependent not only on a rise in the number of blood vessels, but also on factors such as protein molecules produced in en- dothelial cells. Microvessel density (MVD), Microvessel area (MVA), Microvessel perimeter (MVP) can predict the growth of the tumour, metastasis and patient’s survival and this value is related to the aggressiveness of the tumour. Aims: The aim of the present study was to determine the angiogenic potential of OKC and DCcompared with normal mucosa using CD 105 marker immunohistochemically. Materials and methods: Immunohistochemical staining was done on 70 paraffin embedded tissue samples. Histopathologi- cally diagnosed cases of OKC, DC and Pyogenic granuloma and healthy gingival tissue samples were retrieved for the study purpose. Results: There was no statistically significant difference in the mean MVD, MVA, MVP values of OKC, DC and pyogenic granu- loma groups. Conclusion: The angiogenic potential was determined in 3 different cases of OKC, Dentigerous Cyst and Pyogenic granuloma in terms of MVD, MVA and MVP and compared to normal mucosa using CD105 marker immunohistochemically.Though the mean values of MVA, MVD, MVP were statistically not significant but was estimated to be higher than the normal mucosa
ABSTRACT
Introduction: Postoperative pain prevention and treatmentcontinues to be a major challenge in postoperative care.Gabapentin has recently become a part of a wide array ofpostoperative multimodal analgesic regimens. Present studyevaluated the efficacy of oral gabapentin in relief of acutepost-operative pain in laparoscopic cholecystectomy and alsocompared the efficacy of oral Gabapentin with that of oralTramadol.Material and Methods: Sixty ASA I and II physicalstatus patients of both sexes between 20-60 years of agescheduled for elective laparoscopic cholecystectomy wereenrolled into this prospective, double blinded, randomizedsequential allocation study. Any patient who was unwillingand uncooperative, ASA III and IV physical status, patientshaving body weight exceeding 20% of ideal body weight,known hypersensitive to any drug, drug or alcohol abuse,pregnant patient, uncontrolled concomitant medical diseases,history of chronic pain conditions, impaired kidney or liverfunction, laparoscopic cholecystectomy converted to opencholecystectomy, in whom some kind of analgesics wereadministered within 48 hrs of planned surgery were excludedfrom the study.Result: Sixty patients (30 males) were enrolled in the studywith mean ages of all three groups range from 37.40±9.18to 41.70±6.84. However the mean age, weight and sexdistribution among different groups were statisticallyinsignificant (P>0.05). Mean heart rate in various groups atdifferent intervals were insignificant (p>0.05) in the intraoperative period. Among group I, II and III in the postoperativeperiod, changes in mean heart rate was statistically significant(p<0.05). The changes in mean SBP and DBP werestatistically insignificant (p>0.05) intraoperatively in the threegroups.Conclusion: Premedication with oral 300 mg gabapentinprovides better pain relief in the postoperative period ascompare to oral 100 mg tramadol and placebo group withminimal side effects.
ABSTRACT
Soil salinization and alkalinization frequently co-occur in nature. However, only few studies have focused on the interactive effects of mixed salt and alkali stresses on plants. To find supplementary feed source under arid and semiarid conditions, Dichanthium (Forsk.) Stapf. seeds and root cuttings were collected from extreme saline sodic Kachchh plains, Bhuj (Gujrat), and established at ICAR-Central Soil Salinity Research Institute, Karnal. The experiment was designed in RBD having nine different treatments i.e. control (pH2: 7.1; ECe: 0.43), alkaline (pH2: 9.5 and 10.0), saline (ECe: 15, 25 and 35 dS m-1) and saline-alkaline (pH2 9.0 with ECe: 10, 15 and 20 dS m-1). Under alkaline conditions, Dichanthium maintained their plant height but reduction was observed in chlorophyll concentration at both the stresses. Highest photosynthetic rate (Pn) was recorded in control treatment i.e. 36.05 μmol CO2 m-2 s-1 which was decreased with the intensified stress. Reductions were also noticed in the rates of stomatal conductance (gS) and transpiration rate (E) under different stress levels. Dichanthium restrict Na+ accumulation (mean Na+ 0.27%) in root zone whereas in shoots, mean Na+ was 4.58%. Dichanthium maintained or increased shoot K+ concentration under saline and mixed stress condition to mitigate the injurious effect of high Na+ concentration. Among fodder quality parameters, Dichanthium contained 5.15% mean crude protein (CP). Stress treatment caused 10-25% reduction in the CP content over all the stress treatments. Alkalinity, salinity and mixed saline sodic stress caused reduction in neutral detergent fiber (NDF) content but maximum reduction was observed under salinity stress condition. ADF (Acid detergent fiber) content was higher in control (47.44%) and decreased with increasing salt stress. ADL followed the same the trend as shown by ADF.